Topisolon (Desoximetasone) has been used under clinical conditions on 42 patients with acute and chronic dermatoses. This was a comparative trial on symetric areas. Topisolon with the test name A 41 304 has been compared to an 0,1% triamcinolon-acetonide ointment. Topisolon showed a quick onset of action. After 14 days of treatment a good result has been seen in 88% of the cases and in only 5% the effect has been moderate. The drug has been used in psoriasis vulgaris, atopic dermatitis, and lichen ruber. No side effects or irritations have been seen except one case of candidiasis. On five diabetics treated no influence on blood sugar level could be seen.